Citrulline malate (CM) is an amino acid that is derived from the metabolism of arginine and glutamine. Arginine’s effects on the body are well document and the industry has embraced this amino acid for its effects on nitric oxide (NO) production and vasodilation. However, many overlook the significance of CM and the role it has beyond nitric oxide production.
Unlike arginine which has to pass through the liver where it is metabolised into various active compounds leaving less arginine to be converted directly into nitric oxide, CM by-passes hepatic metabolism (liver) resulting in around 80% of ingested CM reaching the kidneys where it can be converted directly into arginine and nitric oxide. Therefore, CM is more effective at increasing endogenous arginine levels than arginine itself. Put simply, this means that CM gives arginine a greater push to be converted into NO which in turn significantly increases vasodilation and circulation.
(Information provided by Gen-Tec Resident Biochemist Dane Ivicevic: BSc, GradDip, GradCert, Dip, TAE)