Why should I take Microgenics Wild Fish Oil 1000mg?
- Joint inflammation, pain and stiffness
- Cardiovascular health, elevated blood fats
- Chronic inflammatory disorders
MICROgenics® Wild Fish Oil 1000mg is an excellent source of Omega-3 fatty acids. These fatty acids can support healthy triglyceride levels in healthy individuals, and a healthy cardiovascular system. At a higher dosage, Omega-3 fatty acids can also help with temporary relief of arthritic pain and symptoms. Sourced from wild, ocean-caught fish and molecularly-distilled to remove pollutants such as mercury and other contaminants without damaging sensitive ingredients.
- For general omega-3 supplementation: take one capsule three times daily with food.
- For cardiovascular health: take two capsules three times daily with food.
- For arthritis relief: take three capsules three times daily with food or as directed by your healthcare professional.
Yeast, starch, gluten, lactose, sugar, artificial colours or flavours, artificial sweeteners or preservatives, or dairy products.
Ingredients (per capsule):
- Fish oil – natural 1000mg
- ncluding Omega-3 Marine triglycerides 300mg
- equiv eicosapentaenoic acid (EPA) 180mg
- equiv docosahexaenoic acid (DHA) 120mg
If symptoms persist, consult your healthcare professional.
Inflammation is a response to tissue damage or other perceived threat, characterised by swelling, heat, redness, and pain. These symptoms are due to immune activity and the release of inflammatory chemicals. Blood flow is increased to deliver immune cells and nutrients to the area affected to protect against infection and heal damaged tissue.
Chronic inflammation is a long-term reaction maintained by continued production of inflammatory compounds which damage tissue in the affected area and cause chronic pain, and swelling, and may lead to loss of function. Causes may include genetic factors, injuries, infections, toxins, allergic reactions, or nutritional deficiencies or imbalances. Chronic inflammation is believed to be a contributing factor to diseases such as osteoarthritis, eczema, dermatitis, asthma, heart disease, Alzheimer’s disease, cancer, and autoimmune disorders, such as multiple sclerosis.
Polyunsaturated fats in cell membranes regulate chronic inflammation
Cell membranes contain a mix of omega-3 & omega-6 polyunsaturated fats. The omega-6 fatty acid, linoleic acid, and the omega-3 fatty acid, alpha-linolenic acid, are both essential in the diet because they cannot be made in the body. They are the starting materials for making pro- and anti-inflammatory eicosanoids, comprising prostaglandins (PG), thromboxanes and leukotrienes. Eicosanoids act like local hormones to regulate cell functions and are produced as required from the breakdown of omega-3 and omega-6 fats in cell membranes.
The correct balance between omega-3 & omega-6 fats is vital for keeping inflammation under control. Modern diets are overloaded with omega-6 fats that form eicosanoids with powerful inflammatory effects. In normal conditions, the enzyme COX-1 helps convert fatty acids to eicosanoids for short-term use in immune defence and healing but in chronic inflammation a variant enzyme, COX-2, is expressed that drives ongoing production of inflammatory eicosanoids, especially PGE2 from the omega-6 fatty acid arachidonic acid, that can cause damage to body tissues. If sufficient omega-3 fats are eaten, they will replace omega-6 fats in cell membranes and be used preferentially to make eicosanoids that are less inflammatory.
Omega-3 fats have anti-inflammatory activity
Step 1. The essential omega-3 fatty acid, alpha-linolenic acid, found in foods such as fatty fish, seafood, fish oil, flaxseed oil, canola oil, and green leafy vegetables, is incorporated into cell membranes and converted to eicosapentaenoic acid (EPA). EPA can also be obtained from fatty fish, seafood, and fish oil, but not from plant foods.
Step 2. EPA in cell membranes is then converted to DHA and pro- and anti-inflammatory eicosanoids by the same enzymes that work on the omega-6 pathway. Prostaglandin I3 is strongly anti-inflammatory but the inflammatory eicosanoids produced are relatively weak compared to those produced from omega-6 fats, and the overall effect is to reduce inflammation. PGE2 and PGE3 both induce COX-2 gene expression but PGE3 is significantly weaker in effect.
Fish oil is a source of alpha-linolenic acid as well as preformed EPA and DHA
Unlike plant sources of omega-3 fats, fatty fish and fish oil contain preformed EPA and DHA. Research has shown that, in humans, alpha-linolenic acid has relatively poor conversion to EPA and even poorer conversion to DHA. If the diet is high in saturated fat, only 6% of a given dose of alpha-linolenic acid is converted to EPA and only 3.8% to DHA, and a diet high in omega-6 fats reduces conversion by 40-50%. EPA and DHA inhibit arachidonic acid metabolism to inflammatory eicosanoids. Fish oil modulates antigen presentation, T-cell reactivity, and production of NF kappaB, interleukins, tumour necrosis factor and inflammatory cytokines, creating a net anti-inflammatory effect.